Vitamin B12 and Reduced Pruritus Severity

• Updated Meta-Analysis on Vitamin Supplementation for Chronic Pruritus: Expanding Evidence Beyond Vitamin D.

  • 2025-04-18
  • Meta-Analysis · n = 21
  • International journal of molecular sciences 26(8)
  • • Wu-Hsien Kuo
    • Ko-Shih Chang
    • Mu-Hsin Chang
    • Yao Hsiao
    • Ru-Yin Tsai

  • PubMed: 40332575
  • DOI: 10.3390/ijms26083840

  1 Insight on

  • Reduced Pruritus Severity

  • High evidence
  • Rigorous Journal

  Subgroup analysis revealed that topical vitamin B12 and vitamin D3 showed the most pronounced antipruritic effects, particularly in patients with atopic dermatitis and chronic kidney disease-associated pruritus.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes