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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin B12 and Reduced Psychotic Symptom Severity

Doses used in studies

μg/day: 500 (median 500, IQR 500–500) — 1 study

Time to effect

Median: 5.6 months · IQR 5.6 months–5.6 months · Range 5.6 months–5.6 months — Reported in 1 of 1 study

1 of 1 paper

Folate and vitamin B12 supplementation in patients with schizophrenia and low serum folate level: A 24-week randomized, double-blind, placebo-controlled study.
- 2026-01
- RCT · n = 36
- Journal of the Formosan Medical Association = Taiwan yi zhi 125(1)
- - Chun-Hsin Chen
  - Chih-Chiang Chiu
  - Yi-Hang Chiu
  - Chin-Hao Chang
  - Yu-Han Chang
  - Ming-Chyi Huang
  - Mong-Liang Lu
  - Po-Yu Chen
- PubMed: 39645464
- DOI: 10.1016/j.jfma.2024.11.019
2 Insights on
- Reduced Psychotic Symptom Severity
- High evidence
- Clinical
There were no significant changes in scores of total and each subscale of PANSS, and Cogstate between the folate and placebo groups.
Effect
Neutral
Effect size
Small
Significant
No
Dose
500 μg/day