Vitamin B12 and Reduced Vitamin B12 Deficiency

• Vitamin B12 supplementation for growth, development, and cognition in children.

  • 2026-06-02
  • Meta-Analysis · n = 4,083
  • The Cochrane database of systematic reviews 2026(6)
  • • Doreen Y Larvie
    • Cristina E Güitrón Leal
    • Sudha Venkatramanan
    • Ximena E Palma Molina
    • Lili B Steel
    • Rebecca Kuriyan
    • Julia L Finkelstein

  • PubMed: 42227307
  • DOI: 10.1002/14651858.cd015264.pub2

  6 Insights on

  • Reduced Vitamin B12 Deficiency

  • High evidence
  • Children

  Vitamin B12 supplementation in children reduces vitamin B12 deficiency (absolute risk difference (ARD) 56 fewer per 1000, 95% CI 68 fewer to 24 fewer; 1.8% versus 7.6%; risk ratio (RR) 0.27, 95% CI 0.11 to 0.69; 3 trials, 642 children; high-certainty evidence)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  0.9 µg/day to 150 µg/day