Vitamin B3 and Improved DLE Lesion Response

• Topical niacinamide (Nicotinamide) treatment for discoid lupus erythematosus (DLE): A prospective pilot study.

  • 2023-01-22
  • RCT · n = 60
  • Journal of cosmetic dermatology 22(5)
  • • Ahmed H Nouh
    • Ahmed R Elshahid
    • Ahmed S Kadah
    • Youssef A Zeyada

  • PubMed: 36683259
  • DOI: 10.1111/jocd.15628

  1 Insight on

  • Improved DLE Lesion Response

  • High evidence
  • Clinical

  Obtained data showed that topical Nicotinamide can be used for the treatment of DLE as adjuvant to other treatment regimens with good cosmetic results and minimal side effects. Topical 4% Nicotinamide is superior to 2% preparation in response but associated with a higher incidence of irritation.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  Topical 2% and 4% preparations in form of cream and gel