A phase I-II study of niacin in patients with newly diagnosed glioblastoma: safety and interim phase II analysis.
- 2025-11-28
- Clinical Trial · n = 24
- Journal of neuro-oncology 176(1)
- Gloria Roldan Urgoiti
- Paula de Robles
- Roger Y Tsang
- Morgan Willson
- Sunita Ghosh
- Muhammad Faruqi
- Gerald Lim
- Shaun Loewen
- Robert Nordal
- Gregory Cairncross
- Catriona Leckie
- Candice C Poon
- V Wee Yong
- PubMed: 41313494
- DOI: 10.1007/s11060-025-05351-z
- Moderate evidence
- Clinical
Interim analysis by central radiology review reported PFS-6 M of 82.3% (CI95% 82.14–82.46%). The interim analysis already showed an absolute increase in PFS-6 M of 28%.
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes
- Dose
- 500–3000 mg/day (Phase I), 2000 mg/day ongoing RP2D