Vitamin B3 and Increased IL-12 Levels

• Niacin Modulates Immune Responses in a Phase I Dose-Escalation Clinical Trial of Newly Diagnosed Glioblastoma.

  • 2026-03
  • Clinical Trial
  • Neurology(R) neuroimmunology & neuroinflammation 13(2)
  • • Candice C Poon
    • Kathleen M Hagen
    • Susobhan Sarkar
    • Reza Mirzaei
    • Claudia Silva
    • Aito Ueno
    • Paula de Robles
    • Gloria Roldan-Urgoiti
    • V Wee Yong

  • PubMed: 41632924
  • DOI: 10.1212/nxi.0000000000200530

  6 Insights on

  • Increased IL-12 Levels

  • Moderate evidence
  • Clinical

  Furthermore, niacin elevated serum levels of the proinflammatory cytokine interleukin (IL)-12p70 and granulocyte colony-stimulating factor and reduced growth-regulated α protein.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  dose escalation