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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin B3 and Reduced Montgomery-Åsberg Depression Rating Scale Score

Doses used in studies

mg single-dose: 100 (median 100, IQR 100–100) — 1 study

Time to effect

Median: 12.2 months · IQR 12.2 months–12.2 months · Range 12.2 months–12.2 months — Reported in 1 of 1 study

1 of 1 paper

Short-Term and Late-Term Effects of Psilocybin on Symptoms in Major Depression: A Randomized Clinical Trial.
- 2026-05-15
- RCT · n = 35
- JAMA network open 9(5)
- - Hampus Yngwe
  - Pontus Plavén-Sigray
  - Carl Johan Ekman
  - Eva Henje
  - Anders Berglund
  - Mikael Tiger
  - Maria Beckman
  - Johan Lundberg
- PubMed: 42138922
- DOI: 10.1001/jamanetworkopen.2026.12589
2 Insights on
- Reduced Montgomery-Åsberg Depression Rating Scale Score
- High evidence
- Rigorous Journal
- Clinical
but no longer on day 365 (mean difference, -3.68; -9.30 to 1.94; P = .20)
Effect
Neutral
Effect size
Small
Significant
No
Dose
100 mg single dose