The efficacy of vitamin B6 as an adjunctive therapy to lithium in improving the symptoms of acute mania in patients with bipolar disorder, type 1; a double-blind, randomized, placebo-controlled, clinical trial.
- 2021-10-17
- RCT · n = 50
- Brain and behavior 11(11)
- Rahim Badrfam
- Seyed-Ali Mostafavi
- Ali Khaleghi
- Shahin Akhondzadeh
- Atefeh Zandifar
- Malihe Farid
- Nami Mohammadian Khonsari
- Mohammad Reza Mohammadi
- PubMed: 34662000
- DOI: 10.1002/brb3.2394
- High evidence
- Clinical
Based on MMSE, significant improvement in cognitive status was obtained in group placebo compared to vitamin B6 group (25.24 ± 1.96 vs. 24.40 ± 3.25, respectively [p-value = .01])
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 80 mg daily