The dihydrofolate reductase 19-bp deletion modifies the beneficial effect of B-vitamin therapy in mild cognitive impairment: pooled study of two randomized placebo-controlled trials.
- 2021-11-12
- RCT
- Human molecular genetics 31(7)
- Yuanyuan Wu
- A David Smith
- Nasser E Bastani
- Helga Refsum
- Timothy Kwok
- PubMed: 34788822
- DOI: 10.1093/hmg/ddab246
- High evidence
- Clinical
The interaction was not significant for memory Z-score and whole brain atrophy rate
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- not specified in abstract