Vitamin B6 and Improved Seizure Control

• Effectiveness of Pyridoxal-5'-Phosphate in PNPO Deficiency: A Systematic Review.

  • 2025-08-02
  • Systematic Review · n = 49
  • Journal of inherited metabolic disease 48(5)
  • • Nina N Stolwijk
    • Laura van Dussen
    • Niels D Reijnhout
    • Marion M M G Brands
    • Bregje Jaeger
    • Peter T Clayton
    • Carla E M Hollak
    • Annet M Bosch

  • PubMed: 40751583
  • DOI: 10.1002/jimd.70074

  1 Insight on

  • Improved Seizure Control

  • High evidence
  • Clinical

  PN being attempted but ineffective in most of them (n = 30/33, 90.9%)

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

• Combination Therapy with Pyridoxine and Arginine Supplementations along with a Lysine-Restricted Diet in Individuals with Pyridoxine-Dependent Epilepsy: A Comprehensive Systematic Review.

  • 2025-08
  • Review
  • Current developments in nutrition 9(8)
  • • Ali Jafari
    • Mohammad Mehdi Abbasi
    • Hamid Abbasi
    • Sama Rahnemayan
    • Farnush Bakhshimoghaddam
    • Saeid Doaei

  • PubMed: 40800672
  • DOI: 10.1016/j.cdnut.2025.107504

  3 Insights on

  • Improved Seizure Control

  • Low evidence
  • Clinical

  pyridoxine monotherapy is a highly effective first-line treatment in PDE that improves seizure control with minimal cognitive decline.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes