Vitamin B6 and Improved Sleep Quality

• The efficacy of vitamin B6 as an adjunctive therapy to lithium in improving the symptoms of acute mania in patients with bipolar disorder, type 1; a double-blind, randomized, placebo-controlled, clinical trial.

  • 2021-10-17
  • RCT · n = 50
  • Brain and behavior 11(11)
  • • Rahim Badrfam
    • Seyed-Ali Mostafavi
    • Ali Khaleghi
    • Shahin Akhondzadeh
    • Atefeh Zandifar
    • Malihe Farid
    • Nami Mohammadian Khonsari
    • Mohammad Reza Mohammadi

  • PubMed: 34662000
  • DOI: 10.1002/brb3.2394

  4 Insights on

  • Improved Sleep Quality

  • High evidence
  • Clinical

  At the Pittsburg scale (total, there was no statistically significant difference between the two groups receiving vitamin B6 and placebo (1.04 ± 0.20 vs. 0.48 ± 0.50 [p-value = .23])

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  80 mg daily

• Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.

  • 2022-12-31
  • RCT · n = 75
  • BMC complementary medicine and therapies 23(1)
  • • Ali Jadidi
    • Alireza Rezaei Ashtiani
    • Ali Khanmohamadi Hezaveh
    • Seyed Mohamad Aghaepour

  • PubMed: 36587225
  • DOI: 10.1186/s12906-022-03814-8

  2 Insights on

  • Improved Sleep Quality

  • High evidence
  • Clinical

  The mean and standard deviation of sleep quality and disease severity at the beginning of the trial and throughout the first month following the intervention did not differ statistically between the three groups.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  40 mg/day