Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo-Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men.
- 2026-03-24
- RCT
- Advanced science (Weinheim, Baden-Wurttemberg, Germany) 13(28)
- Grith Højfeldt
- Joris Michaud
- Ann Damgaard
- Karoline Karlog
- Eugenia Migliavacca
- Sonia Karaz
- Elham Pazirandeh-Micol
- Odd E Johansen
- Leonidas G Karagounis
- Bjørk W Helge
- William Hagemann
- Michael Kjaer
- Jerome N Feige
- Pascal Stuelsatz
- Abigail L Mackey
- PubMed: 41874466
- DOI: 10.1002/advs.202518471
- High evidence
- Adults
the number of Pax7, MyoD, and myogenin positive cells per damaged fiber was significantly higher in NAM/PN vs placebo groups (+29%-67%)
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 19 mg/day