Vitamin B6 and Increased Risk of Gastroesophageal Reflux Disease

• Dietary Vitamin B6 Intake and Gastroesophageal Reflux Disease: A Case-Control Study.

  • 2026-04
  • Observational · n = 150
  • JGH open : an open access journal of gastroenterology and hepatology 10(4)
  • • Amirhesam Mehrara
    • Saba Moradi
    • Masoumeh Dorosti
    • Leila Dehghanian
    • Masoumeh Sadat MirShafaie
    • Mohammadreza Esfahanian
    • Bita Moradi
    • Ali Nouri
    • Sara Khoshdooz
    • Parsa Bahmani
    • Saeid Doaei
    • Maryam Gholamalizadeh

  • PubMed: 41994477
  • DOI: 10.1002/jgh3.70398

  1 Insight on

  • Increased Risk of Gastroesophageal Reflux Disease

  • High evidence

  Compared with participants in the lowest tertile of vitamin B6 intake, those in the highest tertile had significantly higher odds of GERD in age-adjusted models (OR = 1.98, 95% CI: 1.12-3.51) and this association remained significant after further adjustment for sociodemographic factors, physical activity, BMI (OR = 2.05, 95% CI: 1.10-3.83), and total energy intake (OR = 2.02, 95% CI: 1.06-3.81).

  Effect

  Harmful

  Effect size

  Moderate

  Significant

  Yes