Vitamin B6 and Reduced Clinical Dementia Rating Scale-Sum of Boxes Score

• The dihydrofolate reductase 19-bp deletion modifies the beneficial effect of B-vitamin therapy in mild cognitive impairment: pooled study of two randomized placebo-controlled trials.

  • 2021-11-12
  • RCT
  • Human molecular genetics 31(7)
  • • Yuanyuan Wu
    • A David Smith
    • Nasser E Bastani
    • Helga Refsum
    • Timothy Kwok

  • PubMed: 34788822
  • DOI: 10.1093/hmg/ddab246

  5 Insights on

  • Reduced Clinical Dementia Rating Scale-Sum of Boxes Score

  • High evidence
  • Clinical

  significant benefits being observed only in those with ins/ins genotype (Beta = -0.614, P = 0.014)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  not specified in abstract