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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin B6 and Reduced Mania Symptoms

Doses used in studies

mg/day: 80 (median 80, IQR 80–80) — 1 study

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 1 study

1 of 1 paper

The efficacy of vitamin B6 as an adjunctive therapy to lithium in improving the symptoms of acute mania in patients with bipolar disorder, type 1; a double-blind, randomized, placebo-controlled, clinical trial.
- 2021-10-17
- RCT · n = 50
- Brain and behavior 11(11)
- - Rahim Badrfam
  - Seyed-Ali Mostafavi
  - Ali Khaleghi
  - Shahin Akhondzadeh
  - Atefeh Zandifar
  - Malihe Farid
  - Nami Mohammadian Khonsari
  - Mohammad Reza Mohammadi
- PubMed: 34662000
- DOI: 10.1002/brb3.2394
4 Insights on
- Reduced Mania Symptoms
- High evidence
- Clinical
no significant difference was observed between the two groups receiving vitamin B6 and placebo (22.68 ± 5.39 vs. 21.80 ± 5.39 [p-value = .51])
Effect
Neutral
Effect size
Small
Significant
No
Dose
80 mg daily