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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin B9 and Improved Cognitive Function

Doses used in studies

mg/day: 0.8 (median 0.8, IQR 0.8–0.8) — 1 study

Time to effect

Median: 6.1 months · IQR 6.1 months–6.1 months · Range 6.1 months–6.1 months — Reported in 1 of 1 study

1 of 1 paper

Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
- 2026-01
- RCT
- The journal of prevention of Alzheimer's disease 13(1)
- - Yinyue Liu
  - Zili Yu
  - Zhengjun Cai
  - Li Zhao
  - Yu Wang
  - Yajie Guo
  - Xiaonan Su
  - Yuli Miao
  - Bin Yi
  - Yanhong Wang
  - Xumei Zhang
- PubMed: 40945966
- DOI: 10.1016/j.tjpad.2025.100369
1 Insight on
- Improved Cognitive Function
- High evidence
- Clinical
MoCA and MMSE scores improved significantly in the FA group compared to placebo (both P < 0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
0.4 mg/tablet, two tablets daily