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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin B9 and Improved Cognitive Function

Doses used in studies

mg/day: 0.8–5 (median 2.9, IQR 1.85–3.95) — 2 studies

Time to effect

Median: 5.9 months · IQR 5.7 months–6 months · Range 5.6 months–6.1 months — Reported in 2 of 2 studies

2 of 2 papers

Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
- 2026-01
- RCT
- The journal of prevention of Alzheimer's disease 13(1)
- - Yinyue Liu
  - Zili Yu
  - Zhengjun Cai
  - Li Zhao
  - Yu Wang
  - Yajie Guo
  - Xiaonan Su
  - Yuli Miao
  - Bin Yi
  - Yanhong Wang
  - Xumei Zhang
- PubMed: 40945966
- DOI: 10.1016/j.tjpad.2025.100369
1 Insight on
- Improved Cognitive Function
- High evidence
- Clinical
MoCA and MMSE scores improved significantly in the FA group compared to placebo (both P < 0.05).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
0.4 mg/tablet, two tablets daily
Folate and vitamin B12 supplementation in patients with schizophrenia and low serum folate level: A 24-week randomized, double-blind, placebo-controlled study.
- 2026-01
- RCT · n = 36
- Journal of the Formosan Medical Association = Taiwan yi zhi 125(1)
- - Chun-Hsin Chen
  - Chih-Chiang Chiu
  - Yi-Hang Chiu
  - Chin-Hao Chang
  - Yu-Han Chang
  - Ming-Chyi Huang
  - Mong-Liang Lu
  - Po-Yu Chen
- PubMed: 39645464
- DOI: 10.1016/j.jfma.2024.11.019
2 Insights on
- Improved Cognitive Function
- High evidence
- Clinical
There were no significant changes in scores of total and each subscale of PANSS, and Cogstate between the folate and placebo groups.
Effect
Neutral
Effect size
Small
Significant
No
Dose
500 μg/day