l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women.
- 2018-06
- RCT · n = 142
- The Journal of nutrition 148(6)
- Amanda M Henderson
- Rika E Aleliunas
- Su Peng Loh
- Geok Lin Khor
- Sarah Harvey-Leeson
- Melissa B Glier
- David D Kitts
- Tim J Green
- Angela M Devlin
- PubMed: 29878267
- DOI: 10.1093/jn/nxy057
- High evidence
- Large Human Trial
- Adults
The folic acid and l-5-MTHF groups had higher (P < 0.001) RBC folate (mean ± SD: 1498 ± 580 and 1951 ± 496 nmol/L, respectively) and plasma folate [median (25th, 75th percentiles): 40.1 nmol/L (24.9, 52.7 nmol/L) and 52.0 nmol/L (42.7, 73.1 nmol/L), respectively] concentrations compared with RBC folate (958 ± 345 nmol/L) and plasma folate [12.6 nmol/L (8.80, 17.0 nmol/L)] concentrations in the placebo group at 12 wk.
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 1 mg (2.27 μmol)/day