Vitamin B9 and Increased Blood Homocysteine Level

• Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications?

  • 2024-06
  • Review
  • Food and nutrition bulletin 45(1_suppl)
  • • Joshua W Miller
    • Andre Smith
    • Aron M Troen
    • Joel B Mason
    • Paul F Jacques
    • Jacob Selhub

  • PubMed: 38987872
  • DOI: 10.1177/03795721241229503

  4 Insights on

  • Increased Blood Homocysteine Level

  • Low evidence

  Cognitive function test scores are lower and blood homocysteine and methylmalonic acid concentrations are higher in people with low B12 and elevated folate than in those with low B12 and nonelevated folate.

  Effect

  Harmful

  Effect size

  Moderate

  Significant

  Yes

  Dose

  >5 mg/d