Infant blood concentrations of folate markers and catabolites are modified by 5,10-methylenetetrahydrofolate reductase C677T genotype and dietary folate source.
- 2023-03
- RCT · n = 182
- The American journal of clinical nutrition 117(3)
- Rima Obeid
- Ines Warnke
- Anja Wittke
- Igor Bendik
- Barbara Troesch
- Rotraut Schoop
- Christina Hecht
- Johann Demmelmair
- Berthold Koletzko
- PubMed: 36872017
- DOI: 10.1016/j.ajcnut.2022.09.002
- High evidence
- Large Human Trial
- Infants
infant formula with 5-MTHF (vs. folic acid) caused a significant increase in RBC folate concentration [1278 (466) vs. 947 (552), P < 0.001]
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 78 μg per 100 g milk powder