Vitamin B9 and Prevented Deficiency

• Optimizing phenytoin therapy: a systematic review of clinically relevant food and herb interactions.

  • 2026-01-05
  • Systematic Review
  • Frontiers in pharmacology 16
  • • Adriana Monserrath Orellana-Paucar
    • Erick Thomas Mosquera-Lopez
    • Nancy Michelle Bustamante-Alvarez
    • María Gabriela Machado-Orellana
    • Daniela Alejandra Vintimilla-Rojas
    • John Diego Atiencia-Palacios
    • Ana Cristina Espinoza-Fajardo

  • PubMed: 41560756
  • DOI: 10.3389/fphar.2025.1676685

  3 Insights on

  • Prevented Deficiency

  • High evidence

  The review suggests that co-administration of phenytoin with folic acid may prevent deficiency without affecting plasma concentrations or drug efficacy.

  Effect

  Beneficial

  Effect size

  Moderate