The Effect of Maternal Folic Acid Supplementation on Neurodevelopmental Disorders in Offspring: An Umbrella Review of Systematic Reviews and Meta-Analyses.
- 2025-10-31
- Systematic Review · n = 23
- Nutrients 17(21)
- Miao Yu
- Yiming Hu
- Lei Hou
- Xiaomin Wu
- Xiangxin Chen
- Ruohan Yan
- Jie Dong
- Jing Wu
- PubMed: 41228512
- DOI: 10.3390/nu17213443
- High evidence
- Rigorous Journal
MAs indicated a protective effect of supplementation, with odds ratio (OR) of 0.66 (95% CI: 0.55-0.79) for autism spectrum disorder (ASD), 0.86 (95% CI: 0.78-0.95) for attention-deficit/hyperactivity disorder (ADHD), and 0.75 (95% CI: 0.63-0.91) for behavioral problems.
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- not specified