Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction.
- 2025-07-28
- Observational · n = 3,348
- BMC medicine 23(1)
- Shane Gordon
- Leane Hoey
- Helene McNulty
- Jordan Keenan
- Faith Pangilinan
- Lawrence C Brody
- Mary Ward
- J J Strain
- Liadhan McAnena
- Adrian McCann
- Anne M Molloy
- Conal Cunningham
- Kevin McCarroll
- Catherine F Hughes
- PubMed: 40717068
- DOI: 10.1186/s12916-025-04276-8
- High evidence
- Clinical
The abstract reports associations for lower status of vitamin B12, B6, riboflavin, and higher homocysteine, but does not report a significant independent association for folate with cognitive dysfunction in the logistic regression models; folate is mentioned as a B-vitamin in the background but no significant OR is presented for folate in the results.
- Effect
- Neutral
- Effect size
- Small
- Significant
- No