Short-Term Effects of Folate Supplementation in Combination With Vitamin B6 for Treating Acute Manic Episodes in Bipolar I Disorder: A Randomized Controlled Trial.
- 2025-04
- RCT · n = 43
- Brain and behavior 15(4)
- Farzad Akbarzadeh
- Andisheh Talaei
- Mohsen Nematy
- Dina Ganji
- Alireza Ebrahimi
- Ali Talaei
- PubMed: 40200764
- DOI: 10.1002/brb3.70432
- High evidence
- Clinical
the reduction in YMRS scores significantly varied across groups (p < 0.001, effect size = 0.342), with the folate group demonstrating a significantly greater decrease compared to both the folate/B6 (p = 0.003) and placebo groups (p < 0.001).
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 5 mg/day