Vitamin B9 and Reduced Miscarriage Risk

• High versus standard dose folic acid supplementation for miscarriage prevention: systematic review and meta-analysis of randomized controlled trials.

  • 2026-05
  • Meta-Analysis · n = 5,144
  • American journal of obstetrics & gynecology MFM 8(5)
  • • Daniele Vinti
    • Alexander Fiore
    • Gianfranco Fornelli
    • Marco Reschini
    • Paola Viganò
    • Edgardo Somigliana
    • Noemi Salmeri

  • PubMed: 41825593
  • DOI: 10.1016/j.ajogmf.2026.101934

  3 Insights on

  • Reduced Miscarriage Risk

  • High evidence
  • Adults

  An additional intention-to-treat (ITT) analysis, which included all randomized participants regardless of pregnancy status, showed a nonsignificant reduction in miscarriage risk (RR 0.79; 95% CI: 0.61-1.04).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  4-5 mg/day (high dose) vs 0.4 mg/day (standard dose)