Vitamin B9 and Reduced Neural Tube Defect

Doses used in studies

mg/day: 0.4 (median 0.4, IQR 0.4–0.4) — 1 study

2 of 2 papersPopulation:

Association between erythrocyte folate and pregnancy: A scientometric analysis.

2025-09-30
Review · n = 243
Pakistan journal of medical sciences 41(10)
- Yu Xia
- Xuanyi Wang
- Datong Liu
- Limei Sun
- Shen Li
- Meiling Sun

PubMed: 41244549
DOI: 10.12669/pjms.41.10.12671

1 Insight on

Reduced Neural Tube Defect

High evidence

The key studies found that the prevention of NTDs require increased folic acid intake of 0.4mg/day

Effect: Beneficial
Effect size: Large
Significant: Yes
Dose: 0.4 mg/day

Exploring the Impact of Folic Acid Supplementation and Vitamin B12 Deficiency on Maternal and Fetal Outcomes in Pregnant Women with Celiac Disease.

2024-09-21
Review
Nutrients 16(18)
- Lily Lev
- Katherine Petersen
- Joseph L Roberts
- Kevin Kupferer
- Steven Werder

PubMed: 39339794
DOI: 10.3390/nu16183194

8 Insights on

Reduced Neural Tube Defect

Moderate evidence
Rigorous Journal
Mixed

Deficiencies in vitamin B12 are linked with several negative maternal and fetal health outcomes including pre-eclampsia, gestational diabetes, spontaneous abortion/miscarriage, preterm birth, neural tube defects, intrauterine growth restriction, and low gestational age and birthweight.

Effect: Beneficial
Effect size: Large
Significant: Yes