Vitamin B9 and Reduced Neural Tube Defect Mortality

• Profile of neural tube defects in pediatric patients in Nigeria: A systematic review.

  • 2026-03
  • Systematic Review · n = 390
  • Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 145
  • • Nicholas Kendall
    • Joshua Woo
    • Brady K Browning
    • Oluwafemi Owagbemi
    • Temitayo O Ayantayo
    • Sean C Holden-Kapshuck
    • Haley G Kieny
    • Zoey Petitt
    • Megan E H Still
    • Elizabeth Blackwood
    • Bamidele O Adebayo
    • Olawale A R Sulaiman
    • Muhammad R Mahmud
    • Amos O Adeleye
    • Matthew T Shokunbi
    • Michael M Haglund
    • Alvan-Emeka K Ukachukwu

  • PubMed: 41500170
  • DOI: 10.1016/j.jocn.2026.111853

  2 Insights on

  • Reduced Neural Tube Defect Mortality

  • High evidence
  • Clinical

  Mortality trends initially fluctuated, rising from 14.4% (1960-69) to 33.3% (1990-99) before significantly declining to 9.3% (2000-09), 4.6% (2010-19), and 6.0% (2020-23).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes