Vitamin B9 and Reduced Preconception Supplementation

• Does previous pregnancy experience improve folic acid supplementation uptake? A systematic review and meta-analysis.

  • 2026-05
  • Meta-Analysis · n = 855
  • BMJ open 16(5)
  • • Utibe Ebong
    • Jason J Wilson
    • Joanne Given
    • Frank Casey
    • Maria Loane
    • Helen Dolk

  • PubMed: 42082233
  • DOI: 10.1136/bmjopen-2025-106205

  5 Insights on

  • Reduced Preconception Supplementation

  • High evidence
  • Clinical

  Multiparous women were consistently less likely to take folic acid before and during pregnancy than primiparous women. For preconceptional use, the odds were 29% lower among multiparous women (adjusted OR (aOR): 0.71; 95% CI 0.64 to 0.78)

  Effect

  Harmful

  Effect size

  Moderate

  Significant

  Yes