Vitamin B9 and Reduced Preconceptional Supplementation

• Does previous pregnancy experience improve folic acid supplementation uptake? A systematic review and meta-analysis.

  • 2026-05
  • Meta-Analysis · n = 855
  • BMJ open 16(5)
  • • Utibe Ebong
    • Jason J Wilson
    • Joanne Given
    • Frank Casey
    • Maria Loane
    • Helen Dolk

  • PubMed: 42082233
  • DOI: 10.1136/bmjopen-2025-106205

  5 Insights on

  • Reduced Preconceptional Supplementation

  • High evidence
  • Clinical

  58% lower in multiparous high-risk women (aOR: 0.42, 95% CI 0.27 to 0.64)

  Effect

  Harmful

  Effect size

  Large

  Significant

  Yes