Folic acid supplementation in children with sickle cell disease: a randomized double-blind noninferiority cross-over trial.
- 2025-04
- RCT · n = 31
- The American journal of clinical nutrition 121(4)
- Brock A Williams
- Heather McCartney
- Joel Singer
- Angela M Devlin
- Suzanne Vercauteren
- Ali Amid
- John K Wu
- Crystal D Karakochuk
- PubMed: 39921095
- DOI: 10.1016/j.ajcnut.2025.02.001
- High evidence
- Children
The mean [95% confidence interval (CI)] difference in endline RBC folate concentrations across treatments was -179 (-260, -99) nmol/L, with the lower boundary of the CI exceeding noninferiority but the upper boundary not (P = 0.0001; modified intention-to-treat).
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes
- Dose
- 1 mg/d