Vitamin B9 and Reduced Risk of Megaloblastic Anemia

• Folate and global health umbrella review series, part 1: methodological framework and syntheses on anaemia and neural tube defects.

  • 2026-01-30
  • Systematic Review
  • Journal of global health 16
  • • Samantha Yoo
    • Azita Montazeri
    • Derrick Bennett
    • Yacong Bo
    • Peizhan Chen
    • Susan Duthie
    • Natalie Jensen
    • Atipatsa Kaminga
    • Jun-Shi Lai
    • Xue Li
    • Amanda J MacFarlane
    • Homero Martinez
    • Helene McNulty
    • Franco Momoli
    • Peter Mossey
    • Patrick Mullie
    • Ron Munger
    • Rajendra Prasad Parajuli
    • Monique Potvin Kent
    • Michele Rubini
    • Marjanne Senekal
    • Lindsey Sikora
    • Alain Stintzi
    • Evropi Theodoratou
    • Hui Wang
    • Chittaranjan Yajnik
    • Ann Yaktine
    • Julian Little

  • PubMed: 41612855
  • DOI: 10.7189/jogh.16.04014

  2 Insights on

  • Reduced Risk of Megaloblastic Anemia

  • High evidence

  effectiveness of folic acid supplementation during pregnancy in reducing the risk of megaloblastic anaemia (relative risk (RR) = 0.21; 95% CI = 0.11, 0.38; I² = 15%)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes