Vitamin B9 and Reduced Second Trimester Supplementation

• Does previous pregnancy experience improve folic acid supplementation uptake? A systematic review and meta-analysis.

  • 2026-05
  • Meta-Analysis · n = 855
  • BMJ open 16(5)
  • • Utibe Ebong
    • Jason J Wilson
    • Joanne Given
    • Frank Casey
    • Maria Loane
    • Helen Dolk

  • PubMed: 42082233
  • DOI: 10.1136/bmjopen-2025-106205

  5 Insights on

  • Reduced Second Trimester Supplementation

  • High evidence
  • Clinical

  By the second trimester, there was no significant difference between the two parity groups (aOR: 0.96; 95% CI 0.87 to 1.05)

  Effect

  Neutral

  Effect size

  Small

  Significant

  No