Vitamin C and Reduced C-Reactive Protein Levels

• The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.

  • 2025-10-01
  • Meta-Analysis · n = 852
  • BMC musculoskeletal disorders 26(1)
  • • Xiaoya Liu
    • Jiayi Guo
    • Yapeng Li
    • Yidan Yang
    • Mengyao Liu
    • Qi Gao
    • Yuxia Yang
    • Xiaolong Wu
    • Chen Yue

  • PubMed: 41034912
  • DOI: 10.1186/s12891-025-09163-0

  9 Insights on

  • Reduced C-Reactive Protein Levels

  • High evidence

  no significant differences were observed in these outcomes at 48 h postoperatively (P > 0.05)

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

• Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.

  • 2025-04-10
  • RCT · n = 107
  • The Journal of bone and joint surgery. American volume 107(10)
  • • Wenyu Jiang
    • Hong Xu
    • Xue Jiang
    • Yujia Zhan
    • Yucan Ju
    • Jinwei Xie
    • Zeyu Huang
    • Qiang Huang
    • Fuxing Pei

  • PubMed: 40208930
  • DOI: 10.2106/jbjs.24.01080

  8 Insights on

  • Reduced C-Reactive Protein Levels

  • High evidence
  • Large Human Trial
  • Clinical

  demonstrated significantly lower blood levels of C-reactive protein on days 1 and 2

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes