Vitamin C and Reduced Complex Regional Pain Syndrome Recurrence

Doses used in studies

g/day: 1 (median 1, IQR 1–1) — 1 study

Time to effect

Median: 5.7 weeks · IQR 5.7 weeks–5.7 weeks · Range 5.7 weeks–5.7 weeks — Reported in 1 of 1 study

1 of 1 paper

Prophylaxis Against Complex Regional Pain Syndrome Recurrence with Vitamin C in Total Knee Arthroplasty: A Propensity Score-Matched Analysis of 960 Cases.

2025-09-09
Observational · n = 960
The Journal of bone and joint surgery. American volume 107(21)
- Jacques Hernigou
- Esfandiar Chahidi
- Johnatan Everaert
- Liam Sabot
- Alexandre Hupez
- Gauthier Gamela Sedieto
- Antoine Callewier
- Olivier Bath
- Sagi Martinov
- Sagi Martinov

PubMed: 40924823
DOI: 10.2106/jbjs.24.01584

2 Insights on

Reduced Complex Regional Pain Syndrome Recurrence

High evidence
Clinical

In the 28 patients with a history of CRPS, vitamin C prophylaxis reduced the rate of CRPS recurrence after TKA to 19% (4 of 21) compared with 71% (5 of 7) in the patients not treated with vitamin C (OR = 0.09 [95% CI, 0.01 to 0.64], p = 0.02).

Effect: Beneficial
Effect size: Large
Significant: Yes
Dose: 1 g daily for 40 days