Vitamin C and Reduced Duration of Mechanical Ventilation

Doses used in studies

g/kg: 0.5 (median 0.5, IQR 0.5–0.5) — 1 study

Time to effect

Median: 7 days · IQR 7 days–7 days · Range 7 days–7 days — Reported in 1 of 1 study

1 of 1 paper

Role of vitamin C infusion in postoperative mechanically ventilated neonates with sepsis: a randomized controlled trial.

2025-11-29
RCT
European journal of pediatrics 184(12)
- Asmaa Mahmoud Elmesiry
- Mai Rabie Elsheikh
- Khalid Mohamed Elshimy
- Amany Mohamed Abotaleb

PubMed: 41315087
DOI: 10.1007/s00431-025-06625-4

6 Insights on

Reduced Duration of Mechanical Ventilation

High evidence
Infants

Duration of MV (4.44 ± 1.23 vs. 5.64 ± 2.2 days, p = 0.021) and inotropic support needs (40% vs. 76%, p = 0.010) were significantly lower in the Vitamin C group.

Effect: Beneficial
Effect size: Moderate
Significant: Yes
Dose: 0.5 g/kg loading dose followed by a maintenance dose of 0.5 g/kg/h over 6 h, continued for 7 to 10 days