Vitamin C and Reduced F2-Isoprostane Level

• Individual oxidative stress and inflammation responses to vitamin C supplementation: Aggregated sets of n-of-1 trials.

  • 2026-07
  • RCT
  • Free radical biology & medicine 250
  • • George G Nastos
    • Lorenzo Lolli
    • Greg Atkinson
    • Anastasios A Theodorou
    • Vassilis Paschalis
    • Antonios Kyparos
    • Michalis G Nikolaidis
    • Nikos V Margaritelis

  • PubMed: 41935704
  • DOI: 10.1016/j.freeradbiomed.2026.03.073

  3 Insights on

  • Reduced F2-Isoprostane Level

  • High evidence
  • Adults

  Vitamin C supplementation reduced F2-isoprostanes by 25.9 pg/mL (CI: 22.2 to 29.6 pg/mL)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  1 g