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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin C and Reduced Interleukin-10 Levels

Doses used in studies

IU/day: 60,000 (median 60,000, IQR 60,000–60,000) — 1 study
mg/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Time to effect

Median: 2.5 weeks · IQR 12 days–3.3 weeks · Range 7 days–4 weeks — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
We did not observe any changes in the Siddha-based clinical examination and adverse events in both groups.
from: Kabasura Kudineer (KSK), a poly-herbal Siddha medicine, reduced SARS-CoV-2 viral load in a

2 of 2 papers

Gut microbiota links vitamin C supplementation to enhanced mental vitality in healthy young adults with suboptimal vitamin C status: A randomized, double-blind, placebo-controlled trial.
- 2025-08
- RCT · n = 21
- Brain, behavior, and immunity 128
- - Minju Sim
  - Sehwa Hong
  - Min Ho Jung
  - Eun Young Choi
  - Geum-Sook Hwang
  - Dong-Mi Shin
  - Chong-Su Kim
- PubMed: 40187667
- DOI: 10.1016/j.bbi.2025.03.032
6 Insights on
- Reduced Interleukin-10 Levels
- High evidence
- Clinical
responders showed greater decreases in IL-10 levels
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
500 mg twice daily for 4 weeks
Kabasura Kudineer (KSK), a poly-herbal Siddha medicine, reduced SARS-CoV-2 viral load in asymptomatic COVID-19 individuals as compared to vitamin C and zinc supplementation: findings from a prospective, exploratory, open-labeled, comparative, randomized controlled trial, Tamil Nadu, India.
- 2021-09-15
- RCT
- Trials 22(1)
- - S Natarajan
  - C Anbarasi
  - P Sathiyarajeswaran
  - P Manickam
  - S Geetha
  - R Kathiravan
  - P Prathiba
  - M Pitchiahkumar
  - P Parthiban
  - K Kanakavalli
  - P Balaji
- PubMed: 34526104
- DOI: 10.1186/s13063-021-05583-0
7 Insights on
- Reduced Interleukin-10 Levels
- High evidence
- Clinical
There was no significant difference in the biochemical parameters.
Effect
Neutral
Effect size
Small
Significant
No
Dose
100 mg evening daily for 7 days