Vitamin C and Reduced Left Ventricular Ejection Fraction Decline

• Prevention and treatment of anthracycline-induced cardiotoxicity: a systematic review and network meta-analysis of randomized controlled trials.

  • 2025-07-10
  • Review · n = 128
  • Cardio-oncology (London, England) 11(1)
  • • Siyu Li
    • Wenrui Li
    • Mengfei Cheng
    • Xiaoxiao Wang
    • Wanyi Chen

  • PubMed: 40640889
  • DOI: 10.1186/s40959-025-00360-3

  1 Insight on

  • Reduced Left Ventricular Ejection Fraction Decline

  • High evidence
  • Clinical

  Our results indicate that there is insufficient evidence to support the beneficial effects of statins, Sildenafil, Ivabradine, Levocarnitine, N-acetylcysteine, Glutathione, Coenzyme Q10, Vitamin E, and Vitamin C in preventing LVEF decline and exerting a positive effect on the prevention of AIC.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No