Vitamin C and Reduced Mortality

• Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis.

  • 2021-11-09
  • Systematic Review · n = 257
  • Intensive care medicine 48(1)
  • • Tomoko Fujii
    • Georgia Salanti
    • Alessandro Belletti
    • Rinaldo Bellomo
    • Anitra Carr
    • Toshi A Furukawa
    • Nora Luethi
    • Yan Luo
    • Alessandro Putzu
    • Chiara Sartini
    • Yasushi Tsujimoto
    • Andrew A Udy
    • Fumitaka Yanase
    • Paul J Young

  • PubMed: 34750650
  • DOI: 10.1007/s00134-021-06558-0

  4 Insights on

  • Reduced Mortality

  • High evidence
  • Clinical

  There were no significant differences in longer-term mortality between treatments and placebo/usual care or between treatments (10 RCTs, 7,096 patients, moderate to very-low-certainty).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  very-high-dose (≥ 12 g/day), high-dose (< 12, ≥ 6 g/day), or low-dose (< 6 g/day)