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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin C and Reduced Mortality Rate

Doses used in studies

g/day: 1.5 (median 1.5, IQR 1.5–1.5) — 1 study
mg/kg/day: 100 (median 100, IQR 100–100) — 1 study

Time to effect

Median: 3 days · IQR 3 days–3 days · Range 3 days–3 days — Reported in 2 of 2 studies

Safety in these studies

acute kidney injuryNo significant difference
The incidence of prespecified adverse events (acute kidney injury) was similar in both groups.
from: Vitamin C Versus Placebo in Pediatric Septic Shock (VITACiPS) - A Randomised Controlled Tr

2 of 2 papers

Vitamin C Versus Placebo in Pediatric Septic Shock (VITACiPS) - A Randomised Controlled Trial.
- 2025-07-24
- RCT · n = 262
- Journal of intensive care medicine 41(2)
- - Jhuma Sankar
  - Aravindhan Manoharan
  - Rakesh Lodha
  - H P Sharma
  - S K Kabra
- PubMed: 40708328
- DOI: 10.1177/08850666251362121
3 Insights on
- Reduced Mortality Rate
- High evidence
- Large Human Trial
- Clinical
The 28-day mortality was comparable [Vitamin C, 21.6% versus placebo, 22.5%, RR: 0.96 (0.58-1.58), p = 0.88]
Effect
Neutral
Effect size
Small
Significant
No
Dose
25 mg/kg every 6 h for 72 h
The Protective Effect of Vitamin C Targeting Oxidative Stress on Renal Function in Patients with Septic Acute Kidney Injury: A Prospective, Randomized Controlled, Pilot Study.
- 2026-02-04
- RCT · n = 40
- International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 96(1)
- - Yu Chen
  - Min Lu
  - Xuee Shi
  - Fang Feng
  - Jinquan Zhou
- PubMed: 41873106
- DOI: 10.31083/ijvnr38770
5 Insights on
- Reduced Mortality Rate
- High evidence
- Clinical
the mortality rate in ICU was not significantly different (10% vs. 15%, p = 0.633)
Effect
Neutral
Effect size
Small
Significant
No
Dose
1.5 g every 6 h by intravenous infusion for 3 consecutive days