Vitamin C and Reduced N-terminal Pro-B-type Natriuretic Peptide Level

• Pulmonary Hypertension Associated With Vitamin C Deficiency Is Rapidly Reversible.

  • 2026-03-17
  • Case Report
  • Pediatrics 157(4)
  • • Tomás Woodgate
    • Jay Patel
    • Thomas Day
    • Brodie Knight
    • Adriani Spanaki
    • Alistair Calder
    • Shahin Moledina
    • Sadia Quyam

  • PubMed: 41839225
  • DOI: 10.1542/peds.2025-073645

  3 Insights on

  • Reduced N-terminal Pro-B-type Natriuretic Peptide Level

  • Low evidence

  significantly elevated N-terminal pro-B-type natriuretic peptide levels ... all demonstrated rapid clinical and echocardiographic improvement following vitamin C initiation

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes