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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin C and Reduced Platelet Count

Doses used in studies

mg/kg/day: 50 (median 50, IQR 50–50) — 1 study

Time to effect

Median: 4 days · IQR 4 days–4 days · Range 4 days–4 days — Reported in 1 of 1 study

Safety in these studies

mortalityNo significant differenceSerious adverse event
there was no interaction between the effect of vitamin C on mortality and either platelet count at baseline or over time
from: Vitamin C Does Not Affect Platelet Counts in Patients With Sepsis: A Post hoc Analysis of

1 of 1 paper

Vitamin C Does Not Affect Platelet Counts in Patients With Sepsis: A Post hoc Analysis of the Lessening Organ Dysfunction With Vitamin C Randomized Trial.
- 2025-09
- RCT · n = 863
- Critical care explorations 7(9)
- - Mattia M Müller
  - Ruxandra Pinto
  - François Lamontagne
  - Neill K J Adhikari
  - Lorenzo Del Sorbo
- PubMed: 40927646
- DOI: 10.1097/cce.0000000000001310
2 Insights on
- Reduced Platelet Count
- High evidence
- Large Human Trial
- Clinical
These results do not support the hypothesis that vitamin C administration increases mortality risk by affecting platelet count.
Effect
Neutral
Effect size
Small
Significant
No
Dose
50 mg/kg body weight every 6 hours for 4 days