The Role of Vitamin C Supplementation in Total Knee Arthroplasty Outcomes: A Systematic Review of Randomized Controlled Trials.
- 2026-01-01
- Review · n = 364
- The archives of bone and joint surgery 14(3)
- Fardis Vosoughi
- Golnaz Nikeghbalii
- Mohammadhasan Sharafi
- Ehsan Najafi
- Iman Menbari Oskouie
- PubMed: 42137519
- DOI: 10.22038/abjs.2025.92058.4177
- High evidence
- Clinical
Across studies, findings for postoperative pain, inflammatory markers, blood loss, and functional recovery were inconsistent. Several reported numerical trends favors vitamin C, but most outcomes lacked statistical significance or were supported by a single study.
- Effect
- Neutral
- Effect size
- Small
- Significant
- No