Vitamin C and Reduced Risk of Complex Regional Pain Syndrome

• The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.

  • 2025-10-01
  • Meta-Analysis · n = 852
  • BMC musculoskeletal disorders 26(1)
  • • Xiaoya Liu
    • Jiayi Guo
    • Yapeng Li
    • Yidan Yang
    • Mengyao Liu
    • Qi Gao
    • Yuxia Yang
    • Xiaolong Wu
    • Chen Yue

  • PubMed: 41034912
  • DOI: 10.1186/s12891-025-09163-0

  9 Insights on

  • Reduced Risk of Complex Regional Pain Syndrome

  • High evidence

  Vitamin C supplementation may decrease the risk of complex regional pain syndrome (CRPS) and bleeding

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes