Vitamin C and Reduced Uric Acid Levels

Research synthesisLow evidenceSmall effect3 studies · 0 beneficial · 3 neutral · 0 harmful

Across 3 studies, the evidence shows no statistically significant benefit of vitamin C for reducing uric acid levels, with small effect sizes observed but not reaching significance. The most commonly studied dose was 600 mg/day in a short-term (14-day) trial, but findings were neutral across clinical and pregnant populations.

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. All included studies did not reach statistical significance, suggesting that any effect is likely small or absent. Only one study reported a specific dose (600 mg/day), limiting dose-response interpretation.

Generated Jul 10, 2026

Doses used in studies

mg/day: 600 (median 600, IQR 600–600) — 1 study

Time to effect

Median: 2 weeks · IQR 2 weeks–2 weeks · Range 2 weeks–2 weeks — Reported in 1 of 3 studies

Safety in these studies

Overall tolerabilityReported
The study reported no adverse events; none of the participants withdrew due to adverse events.
from: Dietary supplements for chronic gout.

3 of 3 papersPopulation:

Effect of vitamin C and hesperidin on serum uric acid concentrations in healthy adults with high uric acid levels: the randomized controlled 'HesperidrinC trial'.
- 2026-02-25
- RCT · n = 40
- European journal of nutrition 65(2)
- - Janna Enderle
  - Rebecca Dörner
  - Daria Tondar
  - Mario Hasler
  - Caroline Gilcher
  - Christof B Steingass
  - Ralf Schweiggert
  - Manfred J Müller
  - Anja Bosy-Westphal
- PubMed: 41739218
- DOI: 10.1007/s00394-026-03905-z
3 Insights on
- Reduced Uric Acid Levels
- High evidence
- Rigorous Journal
- Clinical
Vitamin C but not hesperidin decreased serum uric acid levels without affecting uric acid excretion.
Effect
Neutral
Effect size
Small
Significant
No
Dose
240 mg/day
Dietary supplements for chronic gout.
- 2021-11-12
- Systematic Review · n = 160
- The Cochrane database of systematic reviews 2022(1)
- - Mariano Andrés
  - Francisca Sivera
  - Rachelle Buchbinder
  - Jordi Pardo Pardo
  - Loreto Carmona
- PubMed: 34767649
- DOI: 10.1002/14651858.cd010156.pub3
1 Insight on
- Reduced Uric Acid Levels
- High evidence
- Clinical
Allopurinol reduced sUA levels more than vitamin C (MD 0.10 mmol/L, 95% CI 0.06 to 0.15), low-quality evidence.
Effect
Neutral
Effect size
Small
Significant
No
Dose
not specified in abstract
Effects of aerobic exercise and antioxidant micronutrients on leptin levels in pregnancy: a sub-analysis from a double-blinded randomised controlled trial.
- 2025-07-09
- RCT
- International journal of food sciences and nutrition 76(6)
- - Milton Fabián Suárez-Ortegón
  - José Guillermo Ortega-Avila
  - Isabella Echeverri
  - Julio Cesar Mateus
  - Mildrey Mosquera
- PubMed: 40634250
- DOI: 10.1080/09637486.2025.2525905
3 Insights on
- Reduced Uric Acid Levels
- High evidence
- Pregnant Women
No significant differences were found for the other interventions ... AMS attenuated this benefit when combined with exercise.
Effect
Neutral
Effect size
Small
Significant
No

Vitamin C and Reduced Uric Acid Levels

Effect of vitamin C and hesperidin on serum uric acid concentrations in healthy adults with high uric acid levels: the randomized controlled 'HesperidrinC trial'.

Dietary supplements for chronic gout.

Effects of aerobic exercise and antioxidant micronutrients on leptin levels in pregnancy: a sub-analysis from a double-blinded randomised controlled trial.