Vitamin C and Reduced Vomiting Frequency

• High-dose Oral Vitamin C Supplementation and Acute Pain Control Following Laparoscopic Cholecystectomy: A Randomized Controlled Study.

  • 2026-04
  • RCT · n = 320
  • Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 41(2)
  • • Yoonyoung Choi
    • Tae Ho Hong

  • PubMed: 41042187
  • DOI: 10.1016/j.jopan.2025.06.008

  5 Insights on

  • Reduced Vomiting Frequency

  • High evidence
  • Large Human Trial
  • Clinical

  the white blood cell count, length of hospital stay, postoperative nausea and vomiting, and postoperative complications were not significantly different between the two groups.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  three 1 g tablets, four times each, both before and after surgery

• Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.

  • 2025-04-10
  • RCT · n = 107
  • The Journal of bone and joint surgery. American volume 107(10)
  • • Wenyu Jiang
    • Hong Xu
    • Xue Jiang
    • Yujia Zhan
    • Yucan Ju
    • Jinwei Xie
    • Zeyu Huang
    • Qiang Huang
    • Fuxing Pei

  • PubMed: 40208930
  • DOI: 10.2106/jbjs.24.01080

  8 Insights on

  • Reduced Vomiting Frequency

  • High evidence
  • Large Human Trial
  • Clinical

  Either treatment was associated with a significantly lower rate of postoperative nausea and vomiting.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes