Vitamin C and Reduced Wheeze

• Vitamin C supplementation to pregnant smokers alters asthma- and allergy-associated CpGs in child buccal DNA at 5 years of age.

  • 2025-10-03
  • RCT · n = 137
  • Clinical epigenetics 17(1)
  • • Lyndsey E Shorey-Kendrick
    • Cindy T McEvoy
    • Kristin Milner
    • Julia Harris
    • Julie Brownsberger
    • Robert S Tepper
    • Byung Park
    • Lina Gao
    • Annette Vu
    • Cynthia D Morris
    • Emma E Thompson
    • Carole Ober
    • Eliot R Spindel

  • PubMed: 41044653
  • DOI: 10.1186/s13148-025-01965-2

  2 Insights on

  • Reduced Wheeze

  • High evidence
  • Large Human Trial
  • Clinical

  We examined the association of buccal DNAm with (1) vitamin C treatment vs placebo, (2) forced expiratory flow between 25 and 75% of expired volume (FEF25-75) and (3) wheeze at 4-6 years of age.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  500 mg/day

• Vitamin A, C and/or E Intake During Pregnancy and Offspring Respiratory Health: A Systematic Review and Meta-Analysis.

  • 2025-07-02
  • Meta-Analysis · n = 213
  • Journal of human nutrition and dietetics : the official journal of the British Dietetic Association 38(4)
  • • Vanessa E Murphy
    • Megan E Jensen
    • Soriah Harvey
    • Tesfalidet Beyene
    • Jake Gregson
    • Farihah Islam
    • William Huang
    • Katie Aistrope
    • Adam Collison

  • PubMed: 40605146
  • DOI: 10.1111/jhn.70086

  2 Insights on

  • Reduced Wheeze

  • High evidence
  • Pregnant Women

  this was not true for vitamin C intake (aOR: 0.85, 95% CI: 0.63-1.16, n=2 observational studies, very low certainty).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  500 mg/day