Vitamin C and Reduced Wheeze

• Vitamin C supplementation to pregnant smokers alters asthma- and allergy-associated CpGs in child buccal DNA at 5 years of age.

  • 2025-10-03
  • RCT · n = 137
  • Clinical epigenetics 17(1)
  • • Lyndsey E Shorey-Kendrick
    • Cindy T McEvoy
    • Kristin Milner
    • Julia Harris
    • Julie Brownsberger
    • Robert S Tepper
    • Byung Park
    • Lina Gao
    • Annette Vu
    • Cynthia D Morris
    • Emma E Thompson
    • Carole Ober
    • Eliot R Spindel

  • PubMed: 41044653
  • DOI: 10.1186/s13148-025-01965-2

  2 Insights on

  • Reduced Wheeze

  • High evidence
  • Large Human Trial
  • Clinical

  We examined the association of buccal DNAm with (1) vitamin C treatment vs placebo, (2) forced expiratory flow between 25 and 75% of expired volume (FEF25-75) and (3) wheeze at 4-6 years of age.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  500 mg/day