Vitamin D and Developed Islet Autoimmunity

• Vitamin supplementation and its effect on incident type 1 diabetes mellitus and islet autoimmunity: a systematic review and meta-analysis.

  • 2025-04-09
  • Meta-Analysis
  • Frontiers in immunology 16
  • • Chen Ee Low
    • Nicole Shi Min Chew
    • Sounak Rana
    • Sean Loke
    • Run Ting Chin
    • Shih Ling Kao
    • Ainsley Ryan Yan Bin Lee
    • Sen Hee Tay

  • PubMed: 40270966
  • DOI: 10.3389/fimmu.2025.1505324

  2 Insights on

  • Developed Islet Autoimmunity

  • High evidence

  Meta-analyses observed that vitamin D did not modify the odds of developing T1DM (Pooled OR=0.55, 95%CI: 0.22-1.38) or IA (Pooled OR=0.91, 95%CI: 0.67-1.25).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No