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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin D and Improved Antioxidant Capacity

Doses used in studies

IU/week: 50,000 (median 50,000, IQR 50,000–50,000) — 1 study

Time to effect

Median: 3.9 months · IQR 2.9 months–5 months · Range 8 weeks–6 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
The study does not report any adverse events, side effects, or safety findings related to the intervention.
from: Vitamin D probiotics fortification improve vitamin D and total antioxidant capacity levels

2 of 2 papersPopulation:

Vitamin D probiotics fortification improve vitamin D and total antioxidant capacity levels among pregnant women: a single-blinded randomized controlled trial.
- 2025-04-07
- RCT
- Scientific reports 15(1)
- - Vivian Ayamah
  - Charles Apprey
  - Eric Owusu Mensah
  - Reginald Adjetey Annan
  - Ebenezer Senu
- PubMed: 40195344
- DOI: 10.1038/s41598-025-87815-w
2 Insights on
- Improved Antioxidant Capacity
- High evidence
- Rigorous Journal
- Pregnant Women
weak TAC (84.8% vs. 15.2%; p = 0.351) were more predominant among pregnant women with inadequate dietary pattern, however not statistically significant
Effect
Neutral
Effect size
Small
Significant
No
Vitamin D3 Supplementation Modulates Inflammatory Protein CHI3L1/YKL-40 and Oxidative Stress Status in Multiple Sclerosis.
- 2025-11-23
- Clinical Trial · n = 35
- Neuropsychopharmacology reports 45(4)
- - Sevda Asadpour
  - Mehrdokht Mazdeh
  - Jamshid Karimi
  - Iraj Khodadadi
  - Gholamreza Shafiee
- PubMed: 41277171
- DOI: 10.1002/npr2.70076
11 Insights on
- Improved Antioxidant Capacity
- High evidence
- Clinical
Antioxidant capacity improved, as demonstrated by elevated TAC (0.622 ± 0.138 to 0.797 ± 0.15 mmol Fe2+/L; p < 0.001)
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
50 000 IU/week