Vitamin D and Improved Flexibility or Set Shift

• High-Dose Vitamin D3 Supplementation During Pregnancy and Test-Based Cognitive Performance at Age 10 Years: A Post Hoc Secondary Analysis of a Randomized Clinical Trial.

  • 2026-05-18
  • RCT · n = 498
  • JAMA network open 9(5)
  • • Olivia Frigast Frederiksen
    • Jens Richardt Møllegaard Jepsen
    • Nicklas Brustad
    • Rebecca Vinding
    • Julie Bøjstrup Rosenberg
    • Parisa Mohammadzadeh
    • María Hernández-Lorca
    • Ann-Marie Malby Schoos
    • Nilo Vahman
    • Birte Y Glenthøj
    • Birgitte Fagerlund
    • Niels Bilenberg
    • Klaus Bønnelykke
    • Bjørn H Ebdrup
    • Kristina Aagaard
    • Bo Chawes

  • PubMed: 42149595
  • DOI: 10.1001/jamanetworkopen.2026.11464

  3 Insights on

  • Improved Flexibility or Set Shift

  • High evidence
  • Large Human Trial
  • Rigorous Journal
  • Children

  high-dose vitamin D3 was no longer associated with flexibility or set shift after multiple test correction.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  2800 IU/day (high-dose) vs 400 IU/day (standard-dose)