Vitamin D and Improved Physical Function

Doses used in studies

IU/day: 200–2,000 (median 1,100, IQR 650–1,550) — 2 studies

Time to effect

Median: 19.2 months · IQR 10.5 months–27.8 months · Range 8 weeks–36.5 months — Reported in 2 of 2 studies

2 of 2 papersPopulation:

Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial.
- 2023-05-10
- RCT · n = 76
- International journal of molecular sciences 24(10)
- - Lena Kopp
  - Anna Schweinlin
  - Lina Tingö
  - Ashley N Hutchinson
  - Viktoria Feit
  - Tabea Jähnichen
  - Katja Lehnert
  - Walter Vetter
  - Andreas Rings
  - Morten G Jensen
  - Robert J Brummer
  - Stephan C Bischoff
- PubMed: 37239916
- DOI: 10.3390/ijms24108567
5 Insights on
- Improved Physical Function
- High evidence
- Rigorous Journal
- Clinical
physical function and mobility improved in the treatment group (p = 0.006).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
200 IU of vitamin D
Effects of vitamin D3, omega-3 fatty acids and a simple home exercise program on change in physical activity among generally healthy and active older adults: The 3-year DO-HEALTH trial.
- 2025-05
- RCT
- The journal of nutrition, health & aging 29(5)
- - Kariem Hussein
  - Melanie Kistler-Fischbacher
  - Michèle Mattle
  - Caroline De Godoi Rezende Costa Molino
  - Li-Tang Tsai
  - Reto W Kressig
  - E John Orav
  - José A P Da Sliva
  - Bruno Vellas
  - René Rizzoli
  - Gabriele Armbrecht
  - Egli Andreas
  - Bess Dawson-Hughes
  - Heike A Bischoff-Ferrari
- PubMed: 40054416
- DOI: 10.1016/j.jnha.2025.100528
5 Insights on
- Improved Physical Function
- High evidence
- Elderly
Vitamin D3, omega-3s or SHEP did not improve physical function.
Effect
Neutral
Effect size
Small
Significant
No
Dose
2000 IU/d

Vitamin D and Improved Physical Function

Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial.

Effects of vitamin D3, omega-3 fatty acids and a simple home exercise program on change in physical activity among generally healthy and active older adults: The 3-year DO-HEALTH trial.